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KMID : 1161920140110020118
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Journal of Medicine and Life Science
2014 Volume.11 No. 2 p.118 ~ p.121
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DRESS syndrome due to Anti-Tuberculous Drug
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Yoo So-Yeon
Lee Jae-Chun
Lee Jong-Hoo
Kim Mi-Ok
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Abstract
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DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) is a potentially life threatening syndrome caused by exposure to certain medications. That may cause skin rash, fever, inflammation of internal organs, lymphadenopathy, and characteristic hematologic abdnormalities such ad eosinophilia, thrombocytopenia, and typical atypical lymphocytosis. The interval between the starting of drug therapy and the onset of cutaneous reactions may be at least one month. Aromatic anticonvulsants (phenytoin, phenobarbital, carbamazepine) and sulfonamides are the most common causes of DRESS. There has been only a few case reports of DRESS syndrome induced by anti-tuberculous medication, Ethambutol, Rifampin, Isoniazid, Pyrazinamide. We report a case of Ethambutol induced DRESS syndrome and multiple drug hypersensitivity to other antituberculosis drugs that were used at after DRESS syndrome developed.
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KEYWORD
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Drug Hypersenitivity Syndrome, ethambutol
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